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Guanabenz (also known as extraneal or adept) belongs to the class of organic compounds known as dichlorobenzenes. Dichlorobenzenes are compounds containing a benzene atom with two chlorine atoms attached to it.1 Guanabenz is an α-2 selective adrenergic agonist that is commonly used as an antihypertensive agent. Guanabenz's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a decrease in peripheral vascular resistance.2
Guanabenz is increasingly being used in racing and other performance horses as a calming agent, and to take the edge off excitable and overly anxious horses to improve their focus and manageability. Guanabenz is a superior solution to the harsher psychotropic drugs which some horse owners have used to help horses through stressful situations.